Based on Patrick Dewitt's acclaimed novel of the same name, follows two brothers – Eli and Charlie Sisters (John C. Reilly and Joaquin Phoenix) – who are hired to kill a prospector who has stolen from their boss. The story, a genre-hybrid with comedic elements, takes place in Oregon in 1851.

The Sisters Brothers is Jacques Audiard's follow-up to his Palme d'Or Winning Dheepan, which premiered at the 2015 Cannes Film Festival. It also stars Jake Gyllenhaal and Riz Ahmed (their second teaming after Nightcrawler), Rutger Hauer, Carol Kane and Creed Bratton.

Catch The Sisters Brothers in theaters this fall and enjoy the trailer below.